FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\RecQ4G7470
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General Information
Symbol
Dmel\RecQ4G7470
Species
D. melanogaster
Name
FlyBase ID
FBal0220932
Feature type
allele
Associated gene
Dmel\RecQ4
Associated Insertion(s)
P{EP}RecQ4G7470
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Bellen, 2009.4.8)
Progenitor genotype
Associated Insertion(s)
P{EP}RecQ4G7470
Cytology
Description

P{EP}RecQ4G7470 is inserted in the 5' untranslated region of RecQ4, 43 base pairs upstream of the translation initiation codon.

(Wu et al., 2008)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      RecQ4G7470 flies are homozygous viable, albeit with a low viability. While male fertlity is unaffected, females are sterile, due to a defect in oogenesis.

      RecQ4G7470 mutant females lay eggs with fragile eggshells and hatch embryos with spiracle defects. No apparent defect is observed in follicle cells during mitotic cycles and endocycles before stage 10B. BrdU incorporation in chorion gene clusters on both the X and third chromosome is greatly reduced in follicle cells of hypomorphic mutants, with incorporation decreased about 5-fold compared to controls.

      (Wu et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      RecQ4G7470 is rescued by RecQ4GFP

      (Wu et al., 2008)
      Comments

      RecQ4T:Avic\GFP fully rescues the infertility of RecQ4G7470 females.

      (Wu et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      RecQ4G7470
      (Bellen, 2009.4.8)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)