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General Information
Symbol
Dmel\bunA-Q578X
Species
D. melanogaster
Name
FlyBase ID
FBal0221056
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C12537923T

Amino acid change:

Q578term | bun-PA; Q469term | bun-PF; Q469term | bun-PG; Q469term | bun-PP

Reported amino acid change:

Q578term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Mutations mapped with respect to isoform -PA.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q578term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mosaic flies with eye and head capsules largely homozygous for bunA-Q578X (generated using the eyFLP/FRT technique) have small heads ("pinhead" phenotype).

Homozygous clones in the wing disc always contain fewer cells than their corresponding wild-type sister clones. The homozygous clones consistently covers a smaller area than the wild-type sister clone, and this reduction in clone area is slightly more pronounced than the reduction in cell number.

bunA-Q578X/bunGE12327 flies show ommatidial differentiation defects, especially around the equator, including under-rotated ommatidia, ommatidial fusions and cell fate transformations (with a low frequency, the R4 photoreceptor cell adopts the fate of the R3 cells and a few R7 cells transform to R1/R6 cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)