FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mltG18151
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General Information
Symbol
Dmel\mltG18151
Species
D. melanogaster
Name
FlyBase ID
FBal0221125
Feature type
allele
Associated gene
Dmel\mlt
Associated Insertion(s)
P{EP}mltG18151
Carried in Construct
Also Known As
CG12214G18151
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Nuwal et al., 2012)
Mutagen
P-element activity
(Bellen, 2009.5.5)
Progenitor genotype
Associated Insertion(s)
P{EP}mltG18151
Cytology
Description
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Individualisation complexes assembled around spermatid nuclear bundles are intact in homozygous, mltG18151/mlt1, mltG18151/mltEY02157 and mltG18151/Df(2R)BSC350 testes, but progressed individualisation complexes (those no longer co-localising with the nuclear bundle) are often disrupted, having one or more investment cones out of register. Sleeves of F-actin associated with highly condensed spermatid bundles at the most basal end of the testis tubule are sometimes seen.

      (Fabrizio et al., 2012)

      Whereas in wild type all 64 investment cones of a spermatogenic cyst stay together and usually move in synchrony along the axoneme bundle, they often lose contact and disperse in mltG18151/mltG18151 mutants.

      Courtship display and success is reduced in mltG18151/mltG18151 males.

      Sperm function per se is not significantly affected by mutation of mlt, as very few offspring result from a cross of mltG18151/mltG18151 females to mlte00818/mlte00818 males, whereas normal numbers of progeny genotypes result from a cross of mltG18151/mltG18151 females to mlte00818/CyO males.

      (Nuwal et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      mlt1

      (Fabrizio et al., 2012)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Although the P{EP}mltG18151 insertion maps within both the CG12214 annotation and an intron of KCNQ (nested genes, CG12214 is entirely within a large intron of KCNQ), complementation analysis indicates that the "mlt" mutant phenotype caused by this insertion (spermatid individualisation defects) is due to an effect on CG12214 and not on KCNQ.

      (Fabrizio et al., 2012)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG12214G18151
      (Fabrizio et al., 2012, Nuwal et al., 2012, Bellen, 2009.5.5)
      mltG18151
      Name Synonyms
      Secondary FlyBase IDs
        References (3)