FlyBase Allele Report: Dmel\pAbp[5-SZ-4029]

General Information

Symbol

Dmel\pAbp^5-SZ-4029

Species

D. melanogaster

Name

FlyBase ID

FBal0222093

Feature type

allele

Associated gene

Dmel\pAbp

Associated Insertion(s)

P{RS5}pAbp^5-SZ-4029

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{RS5}pAbp^5-SZ-4029

Cytology

Description

Allele components

Component

Use(s)

Also carries

FRT

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:18,140,745..18,140,745 [-]

(Blagden et al., 2009, FlyBase Curators, 2008-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle

(Blagden et al., 2009)

female fertile (with Df(2R)Pcl7B)

(Blagden et al., 2009)

male sterile (with Df(2R)Pcl7B)

(Blagden et al., 2009)

viable (with Df(2R)Pcl7B)

(Blagden et al., 2009)

Phenotype Manifest In

centrosome & spermatocyte (with Df(2R)Pcl7B)

(Blagden et al., 2009)

Nebenkern (with pAbp^k10109)

(Blagden et al., 2009)

onion stage spermatid (with Df(2R)Pcl7B)

(Blagden et al., 2009)

onion stage spermatid (with pAbp^k10109)

(Blagden et al., 2009)

onion stage spermatid (with pAbp^SH1908)

(Blagden et al., 2009)

Detailed Description

Statement

Reference

pAbp^5-SZ-4029/Df(2R)Pcl7B cysts in the testis contain only 32 onion-stage spermatids (32 nuclei associated with 32 Nebenkern), instead of the normal number of 64, which indicates that only one meiotic division has occurred in the mutants.

pAbp^5-SZ-4029/pAbp^SH1908 cysts in the testis contain only 32 onion-stage spermatids, instead of the normal number of 64, which indicates that only one meiotic division has occurred in the mutants. In addition 7% of these onion stage spermatids have a ratio of two nuclei to one Nebenkern, revealing a failure of cytokinesis.

pAbp^5-SZ-4029/pAbp^k10109 cysts in the testis sometimes contain spermatids with nuclei and Nebenkern that are twice the size of the surrounding spermatids. Cytokinesis is also affected, resulting in spermatids with a 2:1 and 3:1 ratio of nuclei:Nebenkern (in contrast to the wild-type ratio of 1:1 ).

pAbp^5-SZ-4029/Df(2R)Pcl7B spermatocytes show defects in meiosis; centrosomes fail to become positioned at the nuclear envelope in prophase.

(Blagden et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

126296

w¹¹¹⁸; P{RS5}pAbp^5-SZ-4029

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

pAbp⁴⁰²⁹

(Blagden et al., 2009)

pAbp^5-SZ-4029

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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