FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ero1L335QRS
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General Information
Symbol
Dmel\Ero1L335QRS
Species
D. melanogaster
Name
FlyBase ID
FBal0230252
Feature type
allele
Associated gene
Dmel\Ero1L
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: E436term.

    (Tien et al., 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:4,173,182..4,173,182 [+]
    Nucleotide change:

    G4173182T

    Amino acid change:

    E436term | Ero1L-PB

    Reported amino acid change:

    E436term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Tien et al., 2008)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Ero1L335QRS homozygous somatic MARCM clones in the adult gut contain highly increased number of cells relative to control clones.

        (Wang et al., 2015)

        Ero1L335QRS homozygous mutant clones ehibit a bristle-tufting phenotype on the head epidermis and thorax, in addition to notching of the wing margin and thickening of the wing veins.

        (Tien et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Ero1L335QRS is rescued by Ero1LUAS.cTa/Scer\GAL4αTub84B.PL

        (Tien et al., 2008)
        Comments

        Overexpression of Ero1LScer\uas.cTa under the control of Scer\GAL4αTub84B.PL rescues the tufting phenotype observed in Ero1L335QRS mutants.

        (Tien et al., 2008)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        23T
        (Tien et al., 2008)
        Ero1L335QRS
        Ero1L335qrs
        (Wang et al., 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)