K218term | lsn-PA
Nucleotide substitution: A?T.
Amino acid replacement: K218term.
The premature stop codon is predicted to result in a truncated protein that lacks the C-terminal 36 amino acids of the wild-type product.
endosome | somatic clone | third instar larval stage
eye disc | somatic clone | third instar larval stage
Somatic clones of lsnSS6/lsnSS6 cells in the third instar larval eye disc display low levels of apoptosis (detected by Caspase-3 staining) and show abnormal localization of rho in endosomes.
lsnSS6/lsnSS6 MARCM ddaC clones show dendrite pruning similar to wild type at 18hr APF.
lsnSS6 mutant oocytes rarely contain intralumenal vesicles and isolated multivesicular bodies. They also exhibit irregularly shaped yolk granules.