FB2026_02 , released June 18, 2026
Allele: Dmel\lsnXX3
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General Information
Symbol
Dmel\lsnXX3
Species
D. melanogaster
Name
FlyBase ID
FBal0230474
Feature type
allele
Associated gene
Dmel\lsn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Vaccari et al., 2009)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G?A.

(Vaccari et al., 2009)

Amino acid replacement: W238term.

(Vaccari et al., 2009)

The premature stop codon is predicted to result in a truncated protein that lacks the C-terminal 16 amino acids of the wild-type product.

(Vaccari et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:21,866,121..21,866,121 [+]
Nucleotide change:

G21866121A

Amino acid change:

W238term | lsn-PA

Reported amino acid change:

W238term

Comment:

TGG to TGA nonsense mutation in codon W238@.

(Vaccari et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      lsnXX3 mutant oocytes rarely contain intralumenal vesicles and isolated multivesicular bodies. They also exhibit irregularly shaped yolk granules.

      (Vaccari et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      lsnXX3
      vps22XX3
      (Vaccari et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)