FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\oskbcd.3'UTR.UASp
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General Information
Symbol
Dmel\oskbcd.3'UTR.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0230490
Feature type
allele
Associated gene
Dmel\osk
Associated Insertion(s)
Carried in Construct
P{UASp-osk.bcd.3'UTR}
Key Links
Transgenic product class
wild_type
(Tanaka and Nakamura, 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Tanaka and Nakamura, 2008)
Mutagen
in vitro construct
(Tanaka and Nakamura, 2008)
Progenitor genotype
Carried in construct
P{UASp-osk.bcd.3'UTR}
Cytology
Description

UASp regulatory sequences drive expression of the entire osk open reading frame, which is joined to a modified bcd 3'UTR (the putative NRE sequence, a 45bp HpaI-EcoRV fragment has been replaced by a 10bp SpeI linker).

(Tanaka and Nakamura, 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
osk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of oskbcd.3'UTR.Scer\UAS.P\T under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 induces long F-actin projections at the anterior end of the stage 10b oocyte.

      (Tanaka et al., 2011)

      53% of embryos expressing oskbcd.3'UTR.Scer\UAS.P\T under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 form germ cells in the anterior of the embryo.

      (Gonsalvez et al., 2010)

      Oocytes expressing oskbcd.3'UTR.Scer\UAS.P\T under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 show ectopic incorporation of FM4-64 dye at the anterior of the oocyte. These oocytes have long F-actin projections emanating from cortical actin bundles at the oocyte anterior.

      (Tanaka and Nakamura, 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Scer\GAL4VP16.mat.αTub67C, oskbcd.3'UTR.UASp has filamentous actin & oocyte phenotype, enhanceable by Rbsn-5C241/Rbsn-5C241

      (Tanaka and Nakamura, 2008)
      Suppressed by
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Only 34% of embryos expressing oskbcd.3'UTR.Scer\UAS.P\T under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 in a SmD3P01793 background form germ cells in the anterior of the embryo.

      (Gonsalvez et al., 2010)

      Oocytes of homozygous Rbsn-5C241 female germline clones which are also expressing oskbcd.3'UTR.Scer\UAS.P\T under the control of Scer\GAL4mat.αTub67C.T:Hsim\VP16 show large aberrant F-actin aggregates at the anterior region of the oocyte.

      (Tanaka and Nakamura, 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      oskbcd.3'UTR.Scer\UAS.P\T
      oskbcd.3'UTR.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (7)