Expressing CCT7^KK101540 under the control of Scer\GAL4^ey.PU results in complete loss of head structures in pharate adults.

Expressing CCT7^KK101540 under the control of Scer\GAL4^GMR.PU fails to induce cell death in the posterior compartment of the eye disc in third instar larvae, and results in adults with normal eyes.

The expression of CCT7^KK101540 under the control of either Scer\GAL4^tin.CΔ4 or Scer\GAL4^HCH.Hand leads to a severe decrease in lifespan and leads to a severe decrease in lifespan and leads to a severe decrease in lifespan and leads to near or fully penetrant cardiac defects, respectively, namely morphological defects, non-beating heart segments and non-beating hearts, as compared to controls.

The expression of CCT7^KK101540 under the control of Scer\GAL4^tin.CΔ4 also leads to progressive cardiac dysfunction, as shown by significant increases in heart period, arrhythmia, and diastolic and systolic intervals, and by significant decreases in fractional shortening, and diastolic and systolic diameter, as compared to controls. These hearts show a severe and progressive and progressive disorganization in the actin- and myosin-containing myofibrils, as compared to controls.