FB2026_02 , released June 18, 2026
Allele: Dmel\Inx5KK103391
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General Information
Symbol
Dmel\Inx5KK103391
Species
D. melanogaster
Name
FlyBase ID
FBal0232305
Feature type
allele
Associated gene
Dmel\Inx5
Associated Insertion(s)
Carried in Construct
P{KK103391}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK103391}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK103391
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Inx5KK103391 under the control of Scer\GAL417d, or the split-GAL4 pair of Scer\GAL4DBD.R14C08 and Hsap\RELAAD.R12C11, but not the split-GAL4 pair of Scer\GAL4DBD.R89B01 and Hsap\RELAAD.R13F02, prevents the significant visual short term memory seen in controls following training with pain stimulus in adult flies; no memory defect is seen using Scer\GAL417d when expression is restricted to a smaller subset of cells using Scer\GAL80Mef2.mb247.

      Expression of Inx5KK103391 under the control of Scer\GAL4Mef2.247, or the split-GAL4 pair of Scer\GAL4DBD.R41C07 and Hsap\RELAAD.R13F02, significantly impairs visual short term memory following training with pain stimulus in adult flies, compared to controls; this effect is also seen when Inx5KK103391 is expressed during the adult stage only, under the control of Scer\GAL4Mef2.247.Switch (induced by RU486 application for three days prior to the experiment).

      (Liu et al., 2016)

      Expression of Inx5KK103391 under the control of Scer\GAL4tj.PU (along with expression of UAS-Dcr2 to increase RNAi efficiency) does not cause sterility.

      (Smendziuk et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Inx5KK103391
      inx5KK103391
      (Smendziuk et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)