Expression of Ank2^KK104937 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to enhance RNAi efficiency) results in smaller synapses than normal at the larval neuromuscular junction (there is a signification reduction in synapse area and length). The number of synaptic boutons is reduced and there is an absence of interbouton space.

Flies expressing Ank2^KK104937 under the control of Scer\GAL4^Mef2.247 (in the presence of Dcr-2^Scer\UAS.cDa to enhance RNAi efficiency) show normal learning but significantly reduced short-term memory in the courtship conditioning paradigm.

Expression of Ank2^KK104937 under the control of either Scer\GAL4^elav.PLu or Scer\GAL4^Mef2.247 (in the presence of Dcr-2^Scer\UAS.cDa to enhance RNAi efficiency) has no significant effect on locomotor activity.