FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pgam1KK107771
Open Close
General Information
Symbol
Dmel\Pgam1KK107771
Species
D. melanogaster
Name
FlyBase ID
FBal0235153
Feature type
allele
Associated gene
Dmel\Pgam1
Associated Insertion(s)
Carried in Construct
P{KK107771}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK107771}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK107771
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos expressing Pglym78KK107771 under the control of either Scer\GAL4Mef2.PR or Scer\GAL4kirre.PU show a significant reduction in the size of the segmental border muscle (SBM) and DA1 muscle, and also in the number of nuclei present in these muscles.

      Expression of Pglym78KK107771 under the control of Scer\GAL4Mef2.PR has no effect on heart development in the embryo.

      Expression of Pglym78KK107771 under the control of Scer\GAL4elav.PU has no effect on nervous system development in the embryo.

      Expression of Pglym78KK107771 under the control of Scer\GAL469B has no effect on epidermal development in the embryo.

      (Tixier et al., 2013)

      Embryos expressing Pglym78KK107771 under the control of Scer\GAL4kirre.PU have thinner than normal muscles and contain unfused myoblasts.

      Embryos expressing Pglym78KK107771 under the control of Scer\GAL4kirre.PU show a significant reduction in the size of the segmental border muscle (SBM) and DA1 muscle, and also in the number of nuclei present in these muscles. The defect appears to be due to a premature fusion arrest at 11-11.5 hours after egg laying.

      The number of actin foci in the fusion-competent myoblasts is significantly reduced compared to wild type in stage 13 and 14 embryos expressing Pglym78KK107771 under the control of Scer\GAL4kirre.PU.

      (Tixier et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Pgam1KK107771
      Pglym78KK107771
      Name Synonyms
      Secondary FlyBase IDs
        References (3)