FB2026_03 , released September 17, 2026
Allele: Dmel\Coa8KK108512
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General Information
Symbol
Dmel\Coa8KK108512
Species
D. melanogaster
Name
FlyBase ID
FBal0235617
Feature type
allele
Associated gene
Dmel\Coa8
Associated Insertion(s)
Carried in Construct
P{KK108512}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Keleman et al., 2009.8.5)
Mutagen
in vitro construct
(Keleman et al., 2009.8.5)
Progenitor genotype
Carried in construct
P{KK108512}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-KK108512
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Coa8KK108512 under the control of Scer\GAL4Act5C.PI results in adults that reach the adult stage and have a similar lifespan to controls; there are no alterations in mitochondrial morphology in the thoracic muscle, compared to controls; expression under the control of Scer\GAL4elav-C155 does not cause any alterations in mitochondrial morphology in the brain, compared to controls; expression under the control of either Scer\GAL4Act5C.PI or Scer\GAL4elav-C155 significantly reduces adult locomotor activity, climbing ability and survival under oxidative stress (paraquat), compared to controls.

      (Brischigliaro et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG14806KK108512
      Coa8KK108512
      Name Synonyms
      Secondary FlyBase IDs
        References (3)