FlyBase Allele Report: Dmel\Snx3[KK109353]

General Information

Symbol

Dmel\Snx3^KK109353

Species

D. melanogaster

Name

FlyBase ID

FBal0236256

Feature type

allele

Associated gene

Dmel\Snx3

Associated Insertion(s)

Carried in Construct

P{KK109353}

Also Known As

Snx3 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK109353}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK109353

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

wing margin, with Scer\GAL4^hh.PU

(Harterink et al., 2011, Port et al., 2011)

wing margin | somatic clone, with Scer\GAL4^Act5C.PI

(Harterink et al., 2011)

wing margin bristle, with Scer\GAL4^hh.PU

(Harterink et al., 2011)

wing margin bristle | somatic clone, with Scer\GAL4^Act5C.PI

(Harterink et al., 2011)

Detailed Description

Statement

Reference

Knockdown of Snx3 in the posterior of the wing by expressing Snx3^KK109353 under the control of Scer\GAL4^hh.PU, or by expressing Snx3^KK109353 in clones using Scer\GAL4^Act5C.PI, frequently results in notches and a loss of sensory bristles at the wing periphery.

(Harterink et al., 2011)

Expression of Snx3^KK109353 using Scer\GAL4^hh.PU leads to loss of posterior wing margin tissue.

(Port et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Snx3^KK109353 has phenotype, non-suppressible by Snx1^{UAS.Tag:V5,Tag:polyHis}/Scer\GAL4^en.PU

(Zhang et al., 2011)

Snx3^KK109353 has phenotype, non-suppressible by Scer\GAL4^en.PU/Snx6^{UAS.Tag:V5,Tag:polyHis}

(Zhang et al., 2011)

Suppressor of

Statement

Reference

Snx3^KK109353, Scer\GAL4^ey.PU, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of wg^hs.2sev

(Port et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

wg^hs.2sev rough eyes are suppressed when Snx3^KK109353 is expressed using both Scer\GAL4^ey.PU and Scer\GAL4^GMR.PU.

(Port et al., 2011)

Scer\GAL4^hh.PU-mediated expression of Snx1^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} or Snx6^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} does not restore the wg protein secretion defect in the posterior compartment of Snx3^KK109353, Scer\GAL4^hh.PU wing discs.

(Zhang et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104494

P{KK109353}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG6359^KK109353

Snx3^KK109353

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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