UASt regulatory sequences drive expression of an inverted repeat.
Expression of glob1KK109839 under the control of Scer\GAL4da.G32 in long term hypoxic conditions results in significant reduction in survival rate and median survival time.
Expression of glob1KK109839 under the control of Scer\GAL4da.G32 in short term severe hypoxic conditions results in female flies (but not male) having significantly decreased survival rate.
Expression of glob1KK109839 under the control of Scer\GAL4da.G32 results in significantly reduced recovery time after anoxic stupor in female flies only, but does not affect reaction time to anoxia in either sex.
Expression of glob1KK109839 under the control of Scer\GAL4da.G32 in normoxic conditions results in no significant change in lifespan or length of developmental stages, and in hyperoxic conditions does not change survival rate relative to controls.
Expression of glob1KK109839 under the control of Scer\GAL4da.G32, when exposed to paraquat-induced oxidative stress during 3rd instar larval stage, significantly increases survival to adulthood. When exposed to paraquat-induced oxidative stress during adult stage, expression of glob1KK109839 under the control of Scer\GAL4da.G32 results in significantly higher survival rate of females (but not males) within the first 55hrs of exposure.
No difference in the amount of lipid peroxidation or oxidative DNA damage observed in adult flies expressing glob1KK109839 under the control of Scer\GAL4da.G32 when exposed to oxidative stress via paraquat or hyperoxia.