FlyBase Allele Report: Dmel\Acn[KK111555]

General Information

Symbol

Dmel\Acn^KK111555

Species

D. melanogaster

Name

FlyBase ID

FBal0237496

Feature type

allele

Associated gene

Dmel\Acn

Associated Insertion(s)

Carried in Construct

P{KK111555}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK111555}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK111555

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female fertile, with Scer\GAL4^nanos.PG

(Czech et al., 2013)

increased size | adult stage, with Scer\GAL4^Bx-MS1096

(Tyra et al., 2020)

increased size | adult stage, with Scer\GAL4^en-e16E

(Tyra et al., 2020)

increased size | adult stage, with Scer\GAL4^nub-AC-62

(Tyra et al., 2020)

visible | adult stage, with Scer\GAL4^Bx-MS1096

(Tyra et al., 2020)

visible | adult stage, with Scer\GAL4^en-e16E

(Tyra et al., 2020)

visible | adult stage, with Scer\GAL4^nub-AC-62

(Tyra et al., 2020)

Phenotype Manifest In

wing, with Scer\GAL4^Bx-MS1096

(Tyra et al., 2020)

wing, with Scer\GAL4^en-e16E

(Tyra et al., 2020)

wing, with Scer\GAL4^nub-AC-62

(Tyra et al., 2020)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Acn^KK111555, Scer\GAL4^GMR.PF is an enhancer of abnormal neuroanatomy | progressive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Acn^KK111555, Scer\GAL4^GMR.PF is an enhancer of abnormal neurophysiology | progressive phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

Acn^KK111555, Scer\GAL4^GMR.PF is an enhancer of photoreceptor neuron phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PF

(Nandi et al., 2014)

Suppressor of

Statement

Reference

Acn^KK111555, Scer\GAL4^da.G32 is a suppressor of autophagosome phenotype of Dcp-1^GD10729, Scer\GAL4^da.G32

(Nandi et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Fed or starved larvae experiencing knockdown of both Dcp-1 and Acn (through expression of Dcp-1^GD10729 and Acn^KK111555 under the control of Scer\GAL4^da.G32), display wild-type levels of autophagy, indicating that the remaining protein after Acn knockdown is sufficient to support starvation-induced autophagy but not sufficient to drive elevated levels of basal autophagy in a fed Dcp-1 background.

(Nandi et al., 2014)

Xenogenetic Interactions

Statement

Reference

Knockdown of Acn, through expression of Acn^KK111555 under the control of Scer\GAL4^GMR.PF enhances the neuronal degeneration and depolarization seen in flies expressing Hsap\HTT^{Q93.ex1p.Scer\UAS}.

(Nandi et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v102407

P{KK111555}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Acn^KK111555

hkl^KK111555

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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