FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Spn28DcΔ1
Open Close
General Information
Symbol
Dmel\Spn28DcΔ1
Species
D. melanogaster
Name
FlyBase ID
FBal0239028
Feature type
allele
Associated gene
Dmel\Spn28Dc
Associated Insertion(s)
TI{TI}Spn28DcΔ1
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Scherfer et al., 2008)
Mutagen
recombination
(Scherfer et al., 2008)
gene targeting by homologous recombination
(Scherfer et al., 2008)
Progenitor genotype
Associated Insertion(s)
TI{TI}Spn28DcΔ1
Cytology
Description

3kb deletion removing the Spn28Dc open reading frame. w[+] marker sequences have been inserted in place of the deleted sequence.

(Scherfer et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Approximately 80% of homozygous larvae and pupae show constitutive melanisation. The melanisation occurs mostly in the tracheae and spiracles, with rare melanotic tumours being seen in the hemocoel.

      Homozygous larvae show a stronger melanisation reaction compared to control larvae after injury with a sharp needle, which is visible 2 hours after pricking. The melanisation reaction is localised exclusively to the wound site. Heterozygous larvae also show a stronger melanisation intensity at the wound site after injury compared to wild-type larvae.

      (Scherfer et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      Spn28DcΔ1 has lethal phenotype, non-suppressible by PPO1Bc

      (Scherfer et al., 2008)

      Spn28DcΔ1 has lethal phenotype, non-suppressible by Sp7unspecified

      (Scherfer et al., 2008)

      Spn28DcΔ1 has melanotic mass phenotype phenotype, non-suppressible by Sp7unspecified

      (Scherfer et al., 2008)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Bc1 ; Spn28DΔ1 double mutant larvae do not show melanisation at a wound site, similar to Bc1 single mutants.

      (Scherfer et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Spn28DΔ1
      Spn28DcΔ1
      spn28DΔ1
      (Scherfer et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)