FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mib2RNAi.UAS
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General Information
Symbol
Dmel\mib2RNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0239049
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

UAS regulatory sequences drive expression of a hairpin repeat of a 503bp mib2 fragment (the two copies of the mib2 sequence are separated by an intron sequence).

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

M band & indirect flight muscle, with Scer\GAL41151

myofibril & indirect flight muscle, with Scer\GAL41151

Z disc & indirect flight muscle, with Scer\GAL41151

Detailed Description
Statement
Reference

Expression of mib2dsRNA.Scer\UAS under the control of Scer\GAL41151 results in defects in the indirect flight muscles (IFMs) of newly emerged adults; the M bands are poorly defined, and the Z bands are less dense than normal and occasionally have a zigzagging shape. 2-3 day old flies are flightless and unable to jump and their thoraces have empty cavities, due to a loss of muscle mass. The remaining IFMs lack myofibrils, although both thick and thin filaments are present, and only possess remnants of electron-dense material, which resemble Z bands.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
mib2RNAi.UAS
mib2dsRNA.Scer\UAS
mib2dsRNA.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)