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General Information
Symbol
Dmel\jusJF03192
Species
D. melanogaster
Name
FlyBase ID
FBal0239690
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of jusJF03192 leads to an abnormal paralysis phenotype upon exposure to 10[o]C temperatures (full penetrance if driven by Scer\GAL4elav-C155 or Scer\GAL4ChAT.7.4, high penetrance if driven by Scer\GAL4VGAT.PF and low penetrance if driven by Scer\GAL4VGlut-OK371), which is associated with a significant increase in recovery time from paralysis upon shift to room temperature, as compared to wild-type controls. The Scer\GAL4elav-C155-driven expression also leads to a bang sensitive phenotype if raised at 29[o]C.

Flies expressing jusJF03192 under the control of any of the following: Scer\GAL4ChAT.7.4, Scer\GAL4elav-C155 and Scer\GAL4Act5C.PI are almost all bang sensitive, Scer\GAL4VGAT.PF-driven expression results in a less penetrant phenotype, while expression controlled by either Scer\GAL4VGlut-OK371 or Scer\GAL4repo does not lead to any mechanical shock-induced paralysis. The median time of recovery from the paralysis ranges from ~50 min (with the Scer\GAL4ChAT.7.4 driver) to ~200 min (with Scer\GAL4Act5C.PI).

Expression of jusJF03192 under the control of Scer\GAL4Act5C.PI (combined with tub-Gal80[ts]) kept at moderate levels by keeping the animals at 22[o]C and then increased by shifting the flies to 29[o]C at various points of development (second larval instar, third larval instar, early pupal stage, late pupal stage, eclosion) leads to bang sensitive phenotype in adult flies but the penetrance of the phenotype as well as their median recovery time is significantly lower in flies that have been transfered late in development (as late pupae or adults).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
CG14509JF03192
jusJF03192
Name Synonyms
Secondary FlyBase IDs
    References (3)