FB2026_03 , released September 17, 2026
Allele: Dmel\MiroSd26
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General Information
Symbol
Dmel\MiroSd26
Species
D. melanogaster
Name
FlyBase ID
FBal0239859
Feature type
allele
Associated gene
Dmel\Miro
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Guo et al., 2005)
Progenitor genotype
Cytology
Description

A 39 bp deletion and frame-shifts Miro at I427, adding 12 abnormal amino acids.

(Guo et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA with MiroSd32
      (Tsai et al., 2014)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      mitochondrion & neuron | larval stage (with MiroB682)

      (Guo et al., 2005)
      Detailed Description
      Statement
      Reference

      Gross eye morphology is normal but phototaxis is defective in flies whose eyes are homozygous for MiroSd26.

      In neurons of MiroSd26/MiroB682 larvae, mitochondria are retained in the cell bodies and not properly distributed to neuronal processes - most neuromuscular junctions lack mitochondria.

      In MiroB682/MiroSd26 larvae, excitatory junction potential evoked by 10Hz stimulation of neuro-muscular junctions (NMJs) starts off normal, but, unlike wild-type, rapidly decays.

      (Guo et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DMirosd26
      (Tsai et al., 2014)
      MiroSd26
      Name Synonyms
      Secondary FlyBase IDs
        References (2)