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General Information
Symbol
Dmel\san4
Species
D. melanogaster
Name
FlyBase ID
FBal0240212
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Nucleotide change:

    C11361522T

    Amino acid change:

    Q114term | san-PA

    Reported amino acid change:

    ?114term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Amino acid replacement: ?114term.

    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    87% of embryos derived from homozygous female germline clones have nuclear division abnormalities during the syncytial blastoderm stage. The embryos often show asynchrony of nuclear division and irregular distribution of the nuclei. Chromosome defects are seen during mitosis, with a high frequency of lagging chromosomes and formation of chromosome bridges during anaphase. Interphase nuclei fused together or attached by chromosome bridges are also seen.

    Brain neuroblasts of homozygous larvae have mitotic defects, showing chromosome congression defects during metaphase and chromosome lagging during anaphase.

    Homozygous clones in the imaginal disc are significantly smaller than the twin-spot clones or are absent.

    Females carrying homozygous germ-line clones lay a normal number of eggs for more than 15 days after eclosion. Egg chambers in these females (analysed 7-8 or 15 days after eclosion) show a normal determination of the oocyte, a normal condensed karyosome, a normal number of nurse cells, a normal fusome and produce eggs with a normal eggshell.

    Homozygous clones in the follicle cells are significantly smaller and recovered less frequently than control clones.

    san3/san4 animals pupate but die at the pupal stage.

    san3/san4 third instar larvae have smaller brains than normal and extremely small imaginal discs.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (2)
    Reported As
    Name Synonyms
    Secondary FlyBase IDs
      References (2)