FB2026_03 , released September 17, 2026
Allele: Dmel\Fkbp39UAS.cJa
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General Information
Symbol
Dmel\Fkbp39UAS.cJa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Juhasz
FlyBase ID
FBal0240448
Feature type
allele
Associated gene
Dmel\Fkbp39
Associated Insertion(s)
Carried in Construct
P{UAS-Fkbp39.J}
Key Links
Transgenic product class
cDNA
(Juhász et al., 2007)
wild_type
(Juhász et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Juhász et al., 2007)
wild_type
(Juhász et al., 2007)
Mutagen
in vitro construct
(Juhász et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-Fkbp39.J}
Cytology
Description

UASt regulatory sequences drive expression of the full length Fkbp39 cDNA LD30817.

(Juhász et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Fkbp39
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Very few autolysosomes are seen in fat body cells of wandering larvae expressing FK506-bp1Scer\UAS.cJa under the control of Scer\GAL4Cg.PA, and the autolysosomes seen in the mutant larvae are reduced in size. The nucleoli are greatly enlarged in the mutant cells.

      Expression of FK506-bp1Scer\UAS.cJa under the control of Scer\GAL4Act5C.PP results in inhibition of cell growth in clones in the fat body, with the cells in the overexpressing clones being on average only 32 +/- 21% the size of wild-type neighbouring cells. The clonal cells also have a lower DNA content than their wild-type neighbours.

      Larvae expressing FK506-bp1Scer\UAS.cJa under the control of Scer\GAL4Cg.PA show strong inhibition of the starvation-induced autophagy that is seen in wild-type animals.

      (Juhász et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of PtenScer\UAS.cGb partially restores starvation-induced autophagy in larvae expressing FK506-bp1Scer\UAS.cJa under the control of Scer\GAL4Cg.PA.

      (Juhász et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      FK506-bp1Scer\UAS.cJa
      Fkbp39Scer\UAS.cJa
      Fkbp39UAS.cJa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Juhasz
      Secondary FlyBase IDs
        References (1)