FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dlg1S97-5
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General Information
Symbol
Dmel\dlg1S97-5
Species
D. melanogaster
Name
FlyBase ID
FBal0240610
Feature type
allele
Associated gene
Dmel\dlg1
Associated Insertion(s)
Carried in Construct
Also Known As
dlgS975
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Mendoza-Topaz et al., 2008)
Progenitor genotype
P{GawB}dlg1NP7225
(Mendoza-Topaz et al., 2008)
Cytology
Description

Imprecise excision of the progenitor insertion has resulted in an 8kb deletion that removes exons 1-3 and a portion of exon 4. The deleted sequence is all specific to isoform S97.

(Mendoza-Topaz et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      dlg1S97-5 flies have normal climbing ability and show a normal response in an olfactory avoidance assay (tested with benzaldehyde).

      Adult dlg1S97-5 homozygous flies have severe defects in phototaxis: scores in phototaxis assays are similar to those seen in flies lacking normal phototransduction.

      dlg1S97-5 homozygous males when placed with a single virgin female, spend 40% less time courting than wild-type controls, and only 20% mate within 10 minutes compared to 80% of controls.

      Under alternating light/dark (12 hours) conditions, circadian patterns of locomotor activity in dlg1S97-5 homozygous adults are only slightly abnormal. However, when flies are moved to permanent dark conditions circadian patterns of locomotor activity are gradually lost.

      Electrophysiological readings from the neuromuscular junctions of dlg1S97-5 homozygotes show significantly increased mini excitatory junction potential amplitude and normal evoked excitatory junction potential amplitude. Together these indicate decreased quantal content.

      (Mendoza-Topaz et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dlg1S97-5
      dlgS975
      (Bertin et al., 2022, Mendoza-Topaz et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)