FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hph1
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General Information
Symbol
Dmel\Hph1
Species
D. melanogaster
Name
FlyBase ID
FBal0240642
Feature type
allele
Associated gene
Dmel\Hph
Associated Insertion(s)
P{?PZ}Hph1
Carried in Construct
Also Known As
fga1
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Centanin et al., 2005)
Progenitor genotype
P{PZ}Hph02255
(Centanin et al., 2005)
Associated Insertion(s)
P{?PZ}Hph1
Cytology
Description

Imprecise excision of the progenitor insertion. Approximately 9kb of the original insertion remains.

(Centanin et al., 2005)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Hph1 simaKG07607 double homozygotes are indistinguishable from controls, both in terms of pupal weight and the duration of larval development. Under normoxia conditions, the double homozygotes can survive to adulthood, although 76% of the animals fail to eclose from the pupal case, and those that do emerge look weak and frequently die shortly after eclosion.

      (Centanin et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Hph1 is rescued by HphB.UAS/Scer\GAL4hs.PB

      (Acevedo et al., 2010)

      Hph1 is rescued by Scer\GAL4btl.PS/HphB.UAS

      (Acevedo et al., 2010)
      Partially rescued by

      Hph1 is partially rescued by HphA.UAS/Scer\GAL4hs.PB

      (Acevedo et al., 2010)

      Hph1 is partially rescued by Scer\GAL4btl.PS/HphA.UAS

      (Acevedo et al., 2010)
      Comments

      Expression of HphA.Scer\UAS under the control of Scer\GAL4hs.PB using 30 minute heat shocks once a day partially rescues the lethality of Hph1 mutants, as individuals reach the pupal stage but fail to develop into viable adults.

      Expression of HphB.Scer\UAS under the control of Scer\GAL4hs.PB using 30 minute heat shocks once a day fully rescues the lethality of Hph1 mutants.

      Expression of HphA.Scer\UAS under the control of Scer\GAL4btl.PS partially rescues the air filling defects seen in Hph1 larval tracheal tubules.

      Expression of HphB.Scer\UAS under the control of Scer\GAL4btl.PS almost completely rescues the air filling defects seen in Hph1 larval tracheal tubules.

      (Acevedo et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hph1
      fatiga1
      (Irisarri et al., 2009)
      fga1
      (Acevedo et al., 2010, Centanin et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)