FB2026_03 , released September 17, 2026
Allele: Dmel\OrcoZ4506
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General Information
Symbol
Dmel\OrcoZ4506
Species
D. melanogaster
Name
FlyBase ID
FBal0240759
Feature type
allele
Associated gene
Dmel\Orco
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Or83bZ4506 mutants have a lesion in the splicing donor sequence GTGAGT at the start of intron 3 that is mutated to ATGAGT. Therefore, this intron is not recognized by the splicing machinery and is included in the mature transcript. Inclusion of this intron terminates the Or83b polypeptide prematurely at residue 350.

    (Jin et al., 2008)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3R:5,408,707..5,408,707 [-]
    Nucleotide change:

    G5408707A

    Reported nucleotide change:

    G?A

    Comment:

    Splice donor mutation.

    (Jin et al., 2008)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Or83bZ4506 mutants are defective for cVA (11-cis-vaccenyl acetate) sensitivity but also have striking defects in most olfactory responses.

        Or83bZ4506 mutants exhibit normal CO[[2]] responses but lack responses to general odorants.

        (Jin et al., 2008)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        Or83bZ4506
        (Jin et al., 2008)
        OrcoZ4506
        vainsA1
        (Jin et al., 2008)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)