FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SyndΔEx22
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General Information
Symbol
Dmel\SyndΔEx22
Species
D. melanogaster
Name
FlyBase ID
FBal0240962
Feature type
allele
Associated gene
Dmel\Synd
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Kumar et al., 2009)
Mutagen
P-element activity
(Kumar et al., 2009)
Progenitor genotype
SyndEY07010
(Kumar et al., 2009)
Cytology
Description

Mobilisation of P{EPgy2}SyndEY07010 generates a deletion within Synd.

(Kumar et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The gross morphology of the subsynaptic reticulum of Synd1d/SyndΔEx22 neuromuscular junctions is the same as controls.

      (Kumar et al., 2009)

      Bouton number and axon branching patterns are normal in Synd1d/SyndΔEx22 mutants. The organisaton of synaptic-vesicle clusters appears normal, along with the average fluorescence of various glutamate receptors around each bouton.

      Synd1d/SyndΔEx22 mutants exhibit normal mEJP mplitude, EJP amplitude, and mEJP frequency, compared to controls. In addition, mutant synapses can sustain 5 minutes of high frequency (10Hz) stimulation in 1.5mm Ca[2+], indicating that synaptic-vesicle recycling is not impaired.

      The kinetics of vesicle recycling in Synd1d/SyndΔEx22 mutants is not altered compared to controls.

      (Kumar et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Nostdf004 maternal and zygotic Cip4Δ32 zygotic SyndΔEx22 zygotic triple homozygous mutant embryos exhibit somatic muscle defects (missing muscle fibers with unfused myoblasts), significantly decreased number of nuclei in muscle DA1 and slightly expanded midgut anterior chamber when compared to controls.

      Cip4Δ32 SyndΔEx22 zygotic homozygous double mutant embryos exhibit slightly expanded midgut anterior chamber compared to controls.

      (Schultheis et al., 2019)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      SynddEx22
      (Schultheis et al., 2019)
      SyndΔEx22
      (Kumar et al., 2009)
      syndEx22
      (Kumar et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)