FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\VAPBUAS.cCa
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General Information
Symbol
Hsap\VAPBUAS.cCa
Species
H. sapiens
Name
FlyBase ID
FBal0241349
Feature type
allele
Associated gene
Hsap\VAPB
Associated Insertion(s)
Carried in Construct
P{UAS-Hsap\VAPB.C}
Also Known As
UAS-hVAP
Key Links
Transgenic product class
wild_type
(Chai et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Chai et al., 2008)
Mutagen
in vitro construct
(Chai et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Hsap\VAPB.C}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\VAPB coding sequences.

(Chai et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\VAPB
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis type 8
      modeled by Vap33Δ31
      (Kamemura et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\VAPBScer\UAS.cCa in neurons under the control of Scer\GAL4elav-C155 causes a dramatic increase in the number of boutons with a concomitant decrease in bouton size when compared with controls. Expression of Hsap\VAPBScer\UAS.cCa in a wild-type background causes a reduction in the average mEJP amplitude. A 50% reduction in the mEJP size and about a 10% reduction in the EJP amplitude are observed. Although there is a small decrease in the amplitude of the evoked response, the decrease in quantal size allows a nearly normal post-synaptic response.

      (Chai et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\VAPBScer\UAS.cCa in a Vap-33-1Δ448 mutant background, under the control of Scer\GAL4C164 or Scer\GAL4D42 rescues the larval lethality. Rescued flies are fertile and do not show any obvious morphological or behavioral defects.

      In synapses expressing Hsap\VAPBScer\UAS.cCa under the control of Scer\GAL4C164 or Scer\GAL4D42 in a Vap-33-1Δ448 background, the number of synaptic boutons is similar to controls. Electrophysiological analysis of the same synapses shows that the EJPs and mEJPs are both similar to controls. Hence, the lethality, aberrant NMJ morphology and increased mEJP amplitude associated with loss of Vap-33-1 are rescu

      (Chai et al., 2008)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\VAPBScer\UAS.cCa
      Hsap\VAPBUAS.cCa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)