Overexpression of MlfScer\UAS.cKa in the retina, under the control of Scer\GAL4GMR.PF has little effect on retinal structure.
Co-expression of MlfScer\UAS.cKa with DrefScer\UAS.cSa in the eye under the control of Scer\GAL4GMR.PF does not suppress the eye degeneration observed upon expression of DrefScer\UAS.cSa alone.
Expression of MlfScer\UAS.cKa under the control of Scer\GAL4GMR.PF suppresses the structural and pigmentation defects observed in Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 mutants.
Retina expressing MlfScer\UAS.cKa and prosZzzz\CAG.20Q.Scer\UAS.T:Ivir\HA1 both under the control of Scer\GAL4GMR.PF exhibit a normal morphology.
Retina expressing MlfScer\UAS.cKa and prosZzzz\CAG.127Q.Scer\UAS.T:Ivir\HA1 both under the control of Scer\GAL4GMR.PF results in retinas that are thinner than wild-type and exhibit aberrant tissue morphology.
The presence of one or two copies of MlfScer\UAS.cKa (with the Scer\GAL4GMR.PF driver) suppresses the deterioration of eye structure found in flies expressing Hsap\HDGMR.Q120.
The presence of one or two copies of MlfScer\UAS.cKa (with the Scer\GAL4GMR.PF driver) fails to suppress the deterioration of eye structure after 1 day post eclosion found in flies expressing prosZzzz\CAG.127Q.Scer\UAS.T:Ivir\HA1.
Expression of MlfScer\UAS.cKa under the control of Scer\GAL4Appl.G1a has a protective effect against Zzzz\CAG63Q.Scer\UAS.T:Ivir\HA1 toxicity. At day 20, 55% of flies expressing Zzzz\CAG63Q.Scer\UAS.T:Ivir\HA1 along with MlfScer\UAS.cKa (both under the control of Scer\GAL4Appl.G1a) are still active, while those expressing Zzzz\CAG63Q.Scer\UAS.T:Ivir\HA1 alone are dead.