FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wcd1
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General Information
Symbol
Dmel\wcd1
Species
D. melanogaster
Name
FlyBase ID
FBal0241485
Feature type
allele
Associated gene
Dmel\wcd
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: D277V.

    (Fichelson et al., 2009)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2R:16,346,566..16,346,566 [-]
    Nucleotide change:

    A16346566T

    Amino acid change:

    D277V | wcd-PA

    Reported amino acid change:

    D277V

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Fichelson et al., 2009)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The rate of loss of homozygous wcd1 germline stem cell clones (GSCs) in the ovary as females age is much more pronounced than the rate of loss of wild-type GSCs as females age.

        (Fichelson et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Fails to complement

        wcdk07824

        (Fichelson et al., 2009)
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        wcd1 was isolated a second site mutation on a chromosome also mutant for shgk03401.

        (Fichelson et al., 2009)

        Separable from: shgk03401.

        (Fichelson et al., 2009)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        wcd1
        (Fichelson et al., 2009, Fichelson et al., 2009)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)