FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ImpH149
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General Information
Symbol
Dmel\ImpH149
Species
D. melanogaster
Name
FlyBase ID
FBal0241643
Feature type
allele
Associated gene
Dmel\Imp
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Boylan et al., 2008)
Progenitor genotype
P{PTT-un}ImpPTT
(Boylan et al., 2008)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in a 5.1kb deletion that removes the intron which originally contained the element, as well as several adjacent exons.

(Boylan et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Females containing homozygous germline clones produce phenotypically normal eggs.

      ImpH44/ImpH149 third instar larvae show a significant decrease in the number of boutons per muscle area at the neuromuscular junction compared to controls. The mutant larvae appear somewhat sluggish.

      ImpH44/ImpH149 adult escapers have severe locomotor defects, having highly uncoordinated twitching and grooming leg movements. They frequently fall over as they try to walk and cannot readily right themselves.

      (Boylan et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      H149
      (Boylan et al., 2008)
      ImpH149
      Name Synonyms
      Secondary FlyBase IDs
        References (1)