FlyBase Allele Report: Dmel\Cerk[1]

General Information

Symbol

Dmel\Cerk¹

Species

D. melanogaster

Name

FlyBase ID

FBal0241656

Feature type

allele

Associated gene

Dmel\Cerk

Associated Insertion(s)

P{?GT1}Cerk¹

Carried in Construct

Also Known As

dcerk¹

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Dasgupta et al., 2009)

Progenitor genotype

P{GT1}Cerk^BG01100

(Dasgupta et al., 2009, Dasgupta et al., 2009)

Associated Insertion(s)

P{?GT1}Cerk¹

Cytology

Description

Imprecise excision of the progenitor insertion, leaving approximately 6kb of the original insertion in place. This results in a significant reduction in transcript levels compared to wild type.

(Dasgupta et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology

(Dasgupta et al., 2009)

partially lethal - majority die

(Dasgupta et al., 2009)

viable

(Yuan et al., 2011)

Phenotype Manifest In

eye photoreceptor cell

(Dasgupta et al., 2009, Dasgupta et al., 2009)

rhabdomere

(Dasgupta et al., 2009, Dasgupta et al., 2009)

Detailed Description

Statement

Reference

Homozygous Cerk¹ mutants are viable and have decreased fertility.

(Yuan et al., 2011)

Mutant adults show progressive light induced degeneration of the rhabdomeres; rhabdomeres are seen in 1 day-old flies, but 5- and 17-day old flies have hardly any rhabdomeres and show extensive vacuolation of the photoreceptors.

(Dasgupta et al., 2009)

Mutants show fertility defects.

5-day old mutant adults show severe photoreceptor degeneration; the cells appear vacuolated with almost no intact rhabdomeres. This degeneration phenotype is light-dependent as it is not seen in flies raised in the dark.

Mutant flies raised in the dark do not respond to light stimulus when assayed by electroretinogram recordings.

(Dasgupta et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Cerk¹ has viable phenotype, suppressible by bwa^unspecified/bwa[+]

(Yuan et al., 2011)

Cerk¹ has abnormal neurophysiology phenotype, suppressible by CDase^UAS.cAa/Scer\GAL4^GMR.PF

(Dasgupta et al., 2009)

NOT suppressed by

Statement

Reference

Cerk¹ has abnormal neurophysiology phenotype, non-suppressible by Prosβ6¹

(Dasgupta et al., 2009)

Phenotype Manifest In

Suppressed by

Statement

Reference

Cerk¹ has rhabdomere phenotype, suppressible by CDase^UAS.cAa/Scer\GAL4^GMR.PF

(Dasgupta et al., 2009)

Cerk¹ has eye photoreceptor cell phenotype, suppressible by CDase^UAS.cAa/Scer\GAL4^GMR.PF

(Dasgupta et al., 2009)

NOT suppressed by

Statement

Reference

Cerk¹ has rhabdomere phenotype, non-suppressible by Prosβ6¹

(Dasgupta et al., 2009)

Cerk¹ has eye photoreceptor cell phenotype, non-suppressible by Prosβ6¹

(Dasgupta et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Introduction of bwa^unspecified into a Cerk¹ mutant background results in lethality.

(Yuan et al., 2011)

Expression of CDase^Scer\UAS.cAa under the control of Scer\GAL4^GMR.PF rescues the lack of a light-induced electroretinogram response seen in Cerk¹ flies. The light-induced retinal degeneration that is seen in Cerk¹ flies is also rescued by expression of CDase^Scer\UAS.cAa under the control of Scer\GAL4^GMR.PF.

Pros26¹ cannot rescue the lack of a light-induced electroretinogram response and the retinal degeneration that is seen in Cerk¹ flies.

(Dasgupta et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Cerk¹ is rescued by Scer\GAL4^Act.PU/Cerk^UAS.cDa

(Dasgupta et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Cerk¹

dcerk¹

(Yuan et al., 2011, Dasgupta et al., 2009, Dasgupta et al., 2009)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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