FlyBase Allele Report: Dmel\heca[HM05231]

General Information

Symbol

Dmel\heca^HM05231

Species

D. melanogaster

Name

FlyBase ID

FBal0241722

Feature type

allele

Associated gene

Dmel\heca

Associated Insertion(s)

Carried in Construct

P{TRiP.HM05231}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HM05231}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HM05231

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | third instar larval stage, with Scer\GAL4^en-e16E

(Sun et al., 2020)

Phenotype Manifest In

wing disc | third instar larval stage, with Scer\GAL4^en-e16E

(Sun et al., 2020)

Detailed Description

Statement

Reference

Expression of hdc^HM05231 under the control of Scer\GAL4^en-e16E leads to increased cell death in third instar larval wing discs.

(Sun et al., 2020)

Under a poor-protein diet, expressing hdc^HM05231 under the control of Scer\GAL4^en.PU does not affect the proportion of cell in mitosis (phospho-H3 staining) despite of inducing a mild decrease in cells in S-phase (BrdU labeling) in the wing disc, as compared to controls.

(Li et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

30489

y¹ sc^* v¹ sev²¹; P{TRiP.HM05231}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

hdc^HM05231

heca^HM05231

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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