FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\crn15H6
Open Close
General Information
Symbol
Dmel\crn15H6
Species
D. melanogaster
Name
FlyBase ID
FBal0241860
Feature type
allele
Associated gene
Dmel\crn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Edenfeld et al., 2006)
Progenitor genotype
Cytology
Description

Amino acid replacement: W599term.

(Edenfeld et al., 2006)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,248,009..2,248,009 [-]
Nucleotide change:

G2248009A

Reported nucleotide change:

G?A

Amino acid change:

W599term | crn-PA

Reported amino acid change:

W599term

Comment:

W (TGG) to @(TGA) mutation at W599.

(Edenfeld et al., 2006)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants show defects in glial cell migration in the embryo. Ecol\lacZGli-J29-expressing peripheral glial cells born in the central nervous system (CNS) fail to leave the CNS/peripheral nervous system (PNS) transition zone, and the peripherally derived Ecol\lacZGli-J29-expressing peripheral glial cell fails to migrate towards the CNS. In the mutant embryos, the majority of the Ecol\lacZGli-J29-expressing glial cell body is found close to the CNS/PNS transition zone. The glial cell processes do not wrap the nerves, and instead only thin glial processes project along the nerves, often up to wild-type positions. The morphology of the oenocytes is also affected.

      (Edenfeld et al., 2006)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      15H6
      (Edenfeld et al., 2006)
      crn15H6
      Name Synonyms
      Secondary FlyBase IDs
        References (1)