FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\MadRNAi.UASp
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General Information
Symbol
Dmel\MadRNAi.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0242007
Feature type
allele
Associated gene
Dmel\Mad
Associated Insertion(s)
Carried in Construct
P{UASp-Mad.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Eivers et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Eivers et al., 2009)
Mutagen
in vitro construct
(Eivers et al., 2009)
Progenitor genotype
Carried in construct
P{UASp-Mad.RNAi}
Cytology
Description

UASp regulatory sequences drive expression of an inverted repeat corresponding to an unspecified region of Mad.

(Eivers et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Mad
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When maternal Mad is depleted in embryos by expressing Scer\GAL4mat.αTub67C.T:Hsim\VP16-driven MaddsRNA.Scer\UAS.P\T, embryos display segmental patterning defects. The ventral denticle belts are expanded along the dorso-ventral axis and display fusions between segments. The denticle fusions are caused by lawns of denticles that replace naked cuticle.

      (Eivers et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Expression of MaddsRNA.Scer\UAS.P\T produces dsRNA which results in dsRNA interference (RNAi) of the Mad gene.

      (Eivers et al., 2009)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      MadRNAi.UASp
      MaddsRNA.Scer\UAS.P\T
      MaddsRNA.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (2)