FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Nrx-1JF02652
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General Information
Symbol
Dmel\Nrx-1JF02652
Species
D. melanogaster
Name
FlyBase ID
FBal0242241
Feature type
allele
Associated gene
Dmel\Nrx-1
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02652}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF02652}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02652
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  autism spectrum disorder
      CEA
      (Dong et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Third instar larvae expressing Nrx-1JF02652 under the control of Scer\GAL4αTub84B.PL do not display any neuromuscular junction (NMJ) morphology defects: the total bouton area, number of boutons as well as number of branch points per NMJ is comparable to wild-type.

      (Pandey et al., 2017)

      Flies expressing Nrx-1JF02652 under the control of Scer\GAL4elav.Switch.PO or Scer\GAL4Mef2.247.Switch (and feeding with RU486 to induce expression via the GeneSwitch system) do not exhibit defective learning in an aversive conditioning assay, but do exhibit defects in a reversal-learning paradigm, with a third-odor preference assay showing an inability to forget the first aversive odor association after training with a second aversive odor, as compared to controls.

      (Dong et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The reduced total neuromuscular junction (NMJ) bouton area in third instar larvae expressing Hsap\DISC1Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4αTub84B.PL is rescued by co-expression of Nrx-1JF02652 but this also results in significant decrease in the number of branch points per NMJ, which is not observed in either of the single mutants alone. Number of boutons per NMJ remains comparable to wild-type.

      (Pandey et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Nrx-1JF02652
      Name Synonyms
      Secondary FlyBase IDs
        References (4)