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General Information
Symbol
Dmel\SPARCMI00329
Species
D. melanogaster
Name
FlyBase ID
FBal0242881
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Insertion in the 5' UTR.

    Insertion components
    Mi{MIC}SPARCMI00329
    Product class / Tool use(s)
    Encoded product / tool
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    SPARCMI00329 heterozygote males do not display any heart function parameter defects compared to wild-type.

    SPARCMI00329/SPARCnm136 fat body from 3rd instar larvae shows a disruption of tissue morphology - adipocytes are rounded and membranes bleb. Whereas wild type adipocytes are polygonal, these mutant adipocytes are spherical with an increased number of surface pits.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Suppressor of
    Statement
    Reference

    SPARCMI00329/SPARC[+] is a suppressor of adult heart phenotype of Klf15f06447

    Additional Comments
    Genetic Interactions
    Statement
    Reference

    Partial loss of SPARC expression suppresses the abnormal heart phenotype in hemizygous Klf15f06447 males.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    BM-40-SPARCMI00329
    dSparcMI00329
    Name Synonyms
    Secondary FlyBase IDs
      References (6)