FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SPARCMI00329
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General Information
Symbol
Dmel\SPARCMI00329
Species
D. melanogaster
Name
FlyBase ID
FBal0242881
Feature type
allele
Associated gene
Dmel\SPARC
Associated Insertion(s)
Mi{MIC}SPARCMI00329
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Shahab et al., 2015)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{MIC}SPARCMI00329
    Cytology
    Description

    Insertion in the 5' UTR.

    (Venken et al., 2011)
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{MIC}
    Also carries
    attP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  cardiomyopathy
        modeled by Klf15f06447
        (Hartley et al., 2016)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        SPARCMI00329 heterozygote males do not display any heart function parameter defects compared to wild-type.

        (Hartley et al., 2016)

        SPARCMI00329/SPARCnm136 fat body from 3rd instar larvae shows a disruption of tissue morphology - adipocytes are rounded and membranes bleb. Whereas wild type adipocytes are polygonal, these mutant adipocytes are spherical with an increased number of surface pits.

        (Shahab et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        SPARCMI00329/SPARC[+] is a suppressor of adult heart phenotype of Klf15f06447

        (Hartley et al., 2016)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Partial loss of SPARC expression suppresses the abnormal heart phenotype in hemizygous Klf15f06447 males.

        (Hartley et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        BM-40-SPARCMI00329
        (Bellen, 2010.3.31)
        SPARCMI00329
        (Vaughan et al., 2018, Shahab et al., 2015)
        dSparcMI00329
        (Hartley et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (6)