FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mob2RNAi.UAS.1
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General Information
Symbol
Dmel\Mob2RNAi.UAS.1
Species
D. melanogaster
Name
FlyBase ID
FBal0243044
Feature type
allele
Associated gene
Dmel\Mob2
Associated Insertion(s)
Carried in Construct
P{UAS-Mob2.RNAi.1}
Key Links
Transgenic product class
RNAi_reagent
(Liu et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Liu et al., 2009)
Mutagen
in vitro construct
(Liu et al., 2009)
Progenitor genotype
Carried in construct
P{UAS-Mob2.RNAi.1}
Cytology
Description

UAS sequences drive expression of an inverted repeat of Mob2 amplified from EST clone RE65017 and corresponding to positions 1-320 of the Mob2 coding sequence.

(Liu et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Mob2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Mob2dsRNA.Scer\UAS.IR1 using Scer\GAL4GMR.PF causes the normally regular array of ommatidia to disappear; a cavernous structure often appears in the centre of ommatidia and bristles project randomly on the eye. Internally: the array of photoreceptors is not trapezoid, the shape and size of rhabdomeres is irregular, some rhabdomeres are missing, some rhabdomeres are widely expanded.

      At 35% and 50% pupal development (PD) of Mob2dsRNA.Scer\UAS.IR1, Scer\GAL4GMR.PF eyes, the array of photoreceptor cells is irregular and pigment cells are increased in number and appear in multiple layers. By 75% PD, the array of photoreceptor cells and the shape of rhabdomeres is irregular, and the space between the ommatidia is also irregular.

      (Liu et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Mob2RNAi.UAS.1
      Mob2RNAi.UAS.IR1
      Mob2dsRNA.Scer\UAS.IR1
      Mob2dsRNA.UAS.IR1
      Name Synonyms
      Secondary FlyBase IDs
        References (2)