FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AdoRKG03964ex
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General Information
Symbol
Dmel\AdoRKG03964ex
Species
D. melanogaster
Name
FlyBase ID
FBal0243255
Feature type
allele
Associated gene
Dmel\AdoR
Associated Insertion(s)
Carried in Construct
Also Known As
AdoRKGex
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Wu et al., 2009)
Mutagen
P-element activity
(Wu et al., 2009)
Progenitor genotype
P{SUPor-P}KG03964
(Wu et al., 2009)
Cytology
Description

Imprecise excision of the progenitor insertion has resulted in a 4562bp deletion that removes the entire AdoR open reading frame without affecting any adjacent genes.

(Wu et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous females do not show a significant change in baseline daytime or nighttime sleep under light/dark conditions compared to controls. Baseline sleep is also normal in AdoRKG03964ex/Df(3R)Exel6214 females.

      Homozygous females flies show a significantly increased number of nighttime sleep bouts and a significant reduction in nighttime sleep bout duration compared to controls. Waking activity is not consistently altered in mutants compared to controls.

      Homozygous and AdoRKG03964ex/Df(3R)Exel6214 females have similar amounts of sleep rebound following mechanical sleep deprivation compared to controls. The reduction in sleep latency following sleep deprivation is not altered in mutant flies.

      The affect of caffeine on sleep amount, sleep bout number and sleep bout duration in mutant animals is similar to its effects on controls. The circadian period of mutant flies after caffeine treatment is lengthened to a similar degree as in control flies.

      (Wu et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AdoRKG03964ex
      (Ma et al., 2016)
      AdoRKG
      (Poernbacher and Vincent, 2018)
      AdoRKGex
      (Petitgas et al., 2024, Xu et al., 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)