FB2026_03 , released September 17, 2026
Allele: Dmel\Taf1
Open Close
General Information
Symbol
Dmel\Taf1
Species
D. melanogaster
Name
FlyBase ID
FBal0243435
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes and homozygotes show temperature sensitive paralysis. 100% of homozygotes are paralysed after 10 minutes at 32[o]C (only 2% of heterozygotes are paralysed under these conditions) and 100% of heterozygotes are paralysed after 10 minutes at 35[o]C.

Heterozygotes and homozygotes show recovery from paralysis following exposure to temperatures ranging from 35 to 39[o]C after they are shifted to room temperature. Both show increased recovery times after exposure to increased temperatures. Homozygotes have longer recovery times than heterozygotes.

After exposure to 36[o]C for varying lengths of time, both heterozygotes and homozygotes show increased paralysis recovery times after longer exposure times to the high temperature. Homozygotes have longer recovery times than heterozygotes.

At 22[o]C, the electroretinograms (ERGs) of both heterozygotes and homozygotes have robust on- and off-transients as well as a sustained depolarisation component. After a 5 minute exposures to 37[o]C, the ERGs of both heterozygotes and homozygotes still have on- and off-transients, but the size of the off-transient is reduced to 38% of normal in heterozygotes and 17% of normal in homozygotes. In addition, there is a dramatic decrease in the sustained depolarisation component of the ERG. After shifting back to 22[o]C for 10 minutes, the sustained depolarization component of the ERGs in both heterozygotes and homozygotes is restored to the level seen before shifting to 37[o]C. Recovery of locomotion under these conditions occurs more slowly than the recovery of the ERG response, with recovery of locomotion for 50% of heterozygotes and homozygotes being 8.5 minutes and 46 minutes respectively.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)