Heterozygotes and homozygotes show temperature sensitive paralysis. 100% of homozygotes are paralysed after 10 minutes at 32[o]C (only 2% of heterozygotes are paralysed under these conditions) and 100% of heterozygotes are paralysed after 10 minutes at 35[o]C.
Heterozygotes and homozygotes show recovery from paralysis following exposure to temperatures ranging from 35 to 39[o]C after they are shifted to room temperature. Both show increased recovery times after exposure to increased temperatures. Homozygotes have longer recovery times than heterozygotes.
After exposure to 36[o]C for varying lengths of time, both heterozygotes and homozygotes show increased paralysis recovery times after longer exposure times to the high temperature. Homozygotes have longer recovery times than heterozygotes.
At 22[o]C, the electroretinograms (ERGs) of both heterozygotes and homozygotes have robust on- and off-transients as well as a sustained depolarisation component. After a 5 minute exposures to 37[o]C, the ERGs of both heterozygotes and homozygotes still have on- and off-transients, but the size of the off-transient is reduced to 38% of normal in heterozygotes and 17% of normal in homozygotes. In addition, there is a dramatic decrease in the sustained depolarisation component of the ERG. After shifting back to 22[o]C for 10 minutes, the sustained depolarization component of the ERGs in both heterozygotes and homozygotes is restored to the level seen before shifting to 37[o]C. Recovery of locomotion under these conditions occurs more slowly than the recovery of the ERG response, with recovery of locomotion for 50% of heterozygotes and homozygotes being 8.5 minutes and 46 minutes respectively.