FlyBase Allele Report: Dmel\Srpk79D[VN100]

General Information

Symbol

Dmel\Srpk79D^VN100

Species

D. melanogaster

Name

FlyBase ID

FBal0243483

Feature type

allele

Associated gene

Dmel\Srpk79D

Associated Insertion(s)

Carried in Construct

Also Known As

Srpk79D^VN

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Nieratschker et al., 2009)

Progenitor genotype

P{lacW}Srpk79D^P1

(Nieratschker et al., 2009)

Cytology

Description

An imprecise excision retaining 23 bp of the progenitor P{lacW}srpk79D^P1 that deletes 3861 bp of the srpk79D locus downstream of the progenitor insertion site.

(Nieratschker et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

3L:22,275,357..22,279,217 [+]

Comment:

3861 bp deletion resulting from the imprecise excision of P{lacW}Srpk79D^P1, which removes the transcription and translation starts of many of the Srpk79D transcripts and the first 85 amino acids of the SR kinase domain. 23 bp of the P element remain at the site of the excision.

(Nieratschker et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal flight | recessive

(Nieratschker et al., 2009)

abnormal locomotor behavior | recessive

(Nieratschker et al., 2009)

abnormal neuroanatomy | recessive

(Nieratschker et al., 2009)

short lived | recessive

(Nieratschker et al., 2009)

Phenotype Manifest In

neuron | larval stage

(Nieratschker et al., 2009)

Detailed Description

Statement

Reference

General axonal transport and basic synaptic structure and function appear intact in srpk79D^VN100 mutants.

srpk79D^VN100 mutant larval nerves display larger and more numerous electron-dense ribbon structures resembling T-bars of presynaptic neuromuscular boutons than wild-type controls.

srpk79D^VN100 mutant flies display flight impairment, reduced ability or motivation to walk on a horizontal surface, as well as reduced life span.

(Nieratschker et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Srpk79D^VN100

Srpk79D^VN

(Nieratschker et al., 2009)

srpk79D^VN100

(Johnson et al., 2009)

srpk79D^VN

(Driller et al., 2019)

srpk79D^vn

(Siebert et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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