FlyBase Allele Report: Dmel\jus[iso6.10]

General Information

Symbol

Dmel\jus^iso6.10

Species

D. melanogaster

Name

FlyBase ID

FBal0243573

Feature type

allele

Associated gene

Dmel\jus

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology

(Kuebler et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

The seizure threshold following short wavetrains of high-frequency electrical stimuli (0.5ms pulses at 200Hz for 300ms) is reduced in mutant flies (6.2 +/- 0.8 V) compared to controls.

The threshold for activation of the giant fiber in mutant animals following single stimulus pulses (0.2ms duration, 0.5Hz) is not significantly different from that of wild type.

(Kuebler et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

jus^iso6.10 has abnormal neurophysiology phenotype, suppressible by para^ST76

(Kuebler et al., 2001)

jus^iso6.10 has abnormal neurophysiology phenotype, suppressible | partially by Sh¹⁴

(Kuebler et al., 2001)

jus^iso6.10 has abnormal neurophysiology phenotype, suppressible by shakB²

(Kuebler et al., 2001)

Other

Statement

Reference

jus^iso6.10, mle^nap-ts1 has abnormal neurophysiology phenotype

(Kuebler et al., 2001)

jus^iso6.10, para^ST76 has abnormal neurophysiology phenotype

(Kuebler et al., 2001)

Phenotype Manifest In

Other

Statement

Reference

jus^iso6.10, mle^nap-ts1 has giant fiber neuron phenotype

(Kuebler et al., 2001)

jus^iso6.10, para^ST76 has giant fiber neuron phenotype

(Kuebler et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

para^ST76 suppresses the reduced seizure threshold of sda^iso6.10 flies following high-frequency electrical stimuli, raising the seizure threshold to wild-type levels in the double mutant flies.

The seizure threshold following high-frequency electrical stimuli of mle^nap-ts1 sda^iso6.10 double mutant flies is similar to that seen in mle^nap-ts1 single mutants.

Sh¹⁴ partially suppresses the reduced seizure threshold of sda^iso6.10 flies following high-frequency electrical stimuli.

shakB² suppresses the reduced seizure threshold of sda^iso6.10 flies following high-frequency electrical stimuli, raising the seizure threshold to wild-type levels in the double mutant flies.

The threshold for activation of the giant fiber in sda^iso6.10 Sh¹⁴ and sda^iso6.10 para^ST76 animals following single stimulus pulses (0.2ms duration, 0.5Hz) is not significantly different from that of wild type.

The threshold for activation of the giant fiber in sda^iso6.10 mle^nap-ts1 animals following single stimulus pulses (0.2ms duration, 0.5Hz) is elevated compared to wild type.

The giant fiber following frequency (the maximum stimulation frequency that the giant fiber pathway can reliably follow) of para^ST76 sda^iso6.10 double mutants is reduced compared to either single mutant.

(Kuebler et al., 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG14509^iso6.10

jus^iso6.10

sda^iso6.10

(Kuebler et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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