FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\robo3robo3
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General Information
Symbol
Dmel\robo3robo3
Species
D. melanogaster
Name
FlyBase ID
FBal0243818
Feature type
allele
Associated gene
Dmel\robo3
Associated Insertion(s)
TI{TI}robo3robo3
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
recombination
(Spitzweck et al., 2010)
I-SceI
(Spitzweck et al., 2010)
FLPase
(Spitzweck et al., 2010)
I-CreI
(Spitzweck et al., 2010)
ends-in gene targeting
(Spitzweck et al., 2010)
Progenitor genotype
Associated Insertion(s)
TI{TI}robo3robo3
Cytology
Description

The endogenous exons (and intervening small introns) that encode the mature robo3 protein have been replaced with a single exon encoding full length robo3 tagged with Tag:HA. The exon encoding the signal peptide is derived from the targeted robo3 locus.

(Spitzweck et al., 2010)
Allele components
Component
Use(s)
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The eye photoreceptor cell projections in homozygous robo3robo3.HR.T:Ivir\HA1 flies are indistinguishable from wild-type .

      (Pappu et al., 2011)

      robo3robo3.HR.T:Ivir\HA1 homozygotes do not show the characteristic longitudinal connective phenotypes seen in robo3 null mutants.

      (Spitzweck et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Robo3HA-Robo3
      (González-Ramírez et al., 2022)
      robo3robo3.HR.T:Ivir\HA1
      robo3robo3
      (Carranza et al., 2025, Agcaoili and Evans, 2024, Evans, 2017, Spitzweck et al., 2010)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)