FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Acp36DERNAi.Sym.UAS
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General Information
Symbol
Dmel\Acp36DERNAi.Sym.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0243951
Feature type
allele
Associated gene
Dmel\Acp36DE
Associated Insertion(s)
Carried in Construct
P{symUAS-Acp36DE.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Avila and Wolfner, 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Avila and Wolfner, 2009)
Mutagen
in vitro construct
(Avila and Wolfner, 2009)
Progenitor genotype
Carried in construct
P{symUAS-Acp36DE.RNAi}
Cytology
Description

Two copies of UAS regulatory sequence encompass 93bp of Acp36DE 3'UTR sequences, so generating dsRNA.

(Avila and Wolfner, 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Acp36DE
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mates of Acp36DEdsRNA.Sym.Scer\UAS Scer\GAL4αTub84B.PL males fail to reach the final stage of the uterine conformational changes; the majority of Acp36DEdsRNA.Sym.Scer\UAS knockdown mates appear to have stalled in the 'middle' stages. After stage 5, the reproductive tracts of mates of Acp36DEdsRNA.Sym.Scer\UAS knockdown males do no proceed efficiently, or completely, through the subsequent stages. With the conformational stages blocked at the hourglass stage, the sperm do not condense into a single mass. Instead, the sperm mass remains below the hourglass constriction, becoming more dispersed than normal in the posterior uterus. Sperm storage in Acp36DEdsRNA.Sym.Scer\UAS is approximately 60% of that of controls at 1 hour after the start of mating.

      (Avila and Wolfner, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Acp36DERNAi.Sym.UAS
      Acp36DEdsRNA.Sym.Scer\UAS
      Acp36DEdsRNA.Sym.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)