FB2026_02 , released June 18, 2026
Allele: Dmel\MAN1UAS.cWa
Open Close
General Information
Symbol
Dmel\MAN1UAS.cWa
Species
D. melanogaster
Name
FlyBase ID
FBal0244065
Feature type
allele
Associated gene
Dmel\MAN1
Associated Insertion(s)
Carried in Construct
P{UAS-MAN1.W}
Key Links
Transgenic product class
wild_type
(Wagner et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wagner et al., 2010)
Mutagen
in vitro construct
(Wagner et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-MAN1.W}
Cytology
Description

UASt regulatory sequences drive expression of MAN1 coding sequences.

(Wagner et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
MAN1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Over-expression of MAN1Scer\UAS.cWa in the wing under the control of Scer\GAL4Bx-MS1096 generates defects in the formation of the ACV and the PCV in 90-95% of the emerging adults. The phenotypes range from 'gaps', where the PCV shows a gap either from L4 or L5, 'points', where the PCV is reduced to a point, or 'PCV absent', and 'CV absent', where the PCV or both CVs are missing. In addition, the tip of the longitudinal vein L4 is often compromised leading to truncations.

      (Wagner et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Act5C.PI/MAN1UAS.cWa rescues MAN1ΔC

      (Wagner et al., 2010)
      Partially rescues

      Scer\GAL4elav-C155/MAN1UAS.cWa partially rescues MAN1ΔC

      (Wagner et al., 2010)

      Scer\GAL4Mef2.PR/MAN1UAS.cWa partially rescues MAN1ΔC

      (Wagner et al., 2010)

      MAN1UAS.cWa partially rescues MAN1ΔC

      (Wagner et al., 2010)
      Comments

      The climbing defect of MAN1ΔC flies can be rescued by expression of MAN1Scer\UAS.cWa under the ubiquitous Scer\GAL4Act5C.PI driver.

      Expression of MAN1Scer\UAS.cWa within the presynaptic motoneuron, using the neuronal driver Scer\GAL4elav-C155 or within the post-synaptic muscle with the Scer\GAL4Mef2.PR driver is not sufficient to fully restore motor ability.

      Partial rescue of MAN1ΔC mutants is observed through the introduction of one or two copies of MAN1Scer\UAS.cWa without a Scer\GAL4 driver. Both motor ability and synaptic phenotypes are partially rescued.

      Both the pre- and post-synaptic expression of MAN1Scer\UAS.cWa (under the control of Scer\GAL4Mef2.PR or Scer\GAL4elav-C155 can partially rescue the drop in EPSC amplitude detected in MAN1ΔC larvae.

      (Wagner et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      MAN1Scer\UAS.cWa
      MAN1UAS.cWa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)