FB2026_02 , released June 18, 2026
Allele: Dmel\LarD1YLCS.UAS
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General Information
Symbol
Dmel\LarD1YLCS.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0244105
Feature type
allele
Associated gene
Dmel\Lar
Associated Insertion(s)
Carried in Construct
P{UAS-Lar.D1YLCS}
Key Links
Transgenic product class
missense_variant
(Hofmeyer and Treisman, 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Hofmeyer and Treisman, 2009)
Mutagen
in vitro construct
(Hofmeyer and Treisman, 2009)
Progenitor genotype
LarC1638S.UAS
(Hofmeyer and Treisman, 2009)
Carried in construct
P{UAS-Lar.D1YLCS}
Cytology
Description

UAS regulatory sequences drive expression of a modified form of Lar, carrying two point mutations which modify residues in its D1 domain (cysteine to serine, and tyrosine (Y1054) to leucine).

(Hofmeyer and Treisman, 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Lar
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4elav-C155/LarD1YLCS.UAS partially rescues LarC12/Lar2127

      (Hofmeyer and Treisman, 2009)
      Comments

      Expression of LarD1YLCS.Scer\UAS under the control of Scer\GAL4elav-C155 in LarC12/Lar2127 mutant eye discs rescues axon mistargeting.

      Expression of LarD1YLCS.Scer\UAS under the control of Scer\GAL4elav-C155 only partially promotes synaptic growth at the neuromuscular junction in LarC12/Lar2127 mutant larvae.

      (Hofmeyer and Treisman, 2009)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      LarD1YLCS.Scer\UAS
      LarD1YLCS.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)