FlyBase Allele Report: Dmel\haf[NIG.14351R]

General Information

Symbol

Dmel\haf^NIG.14351R

Species

D. melanogaster

Name

FlyBase ID

FBal0244125

Feature type

allele

Associated gene

Dmel\haf

Associated Insertion(s)

Carried in Construct

P{NIG.14351R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Kurusu et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Kurusu et al., 2008)

Mutagen

in vitro construct

(Kurusu et al., 2008)

Progenitor genotype

Carried in construct

P{NIG.14351R}

Cytology

Description

UASt sequences control expression of an inverted repeat of haf for RNAi.

(Kurusu et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-14351R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage, with Scer\GAL4^Tub.PU

(Kurusu et al., 2008)

some die during embryonic stage, with Scer\GAL4^Tub.PU

(Kurusu et al., 2008)

Phenotype Manifest In

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage, with Scer\GAL4^Tub.PU

(Kurusu et al., 2008)

Detailed Description

Statement

Reference

Stage 17 haf^NIG-14351R; Scer\GAL4^how-24B embryos display a range of defects in the trajectory of the ISNb with a penetrance of around 30%. ISNb defects include truncation and bypassing the ventral-lateral muscle field (the normal targets for innervation by ISNb).

haf^NIG-14351R Scer\GAL4^αTub84B.PL is embryonic lethal.

(Kurusu et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference