FlyBase Allele Report: Dmel\hh[NIG.4637R]

General Information

Symbol

Dmel\hh^NIG.4637R

Species

D. melanogaster

Name

FlyBase ID

FBal0244619

Feature type

allele

Associated gene

Dmel\hh

Associated Insertion(s)

Carried in Construct

P{NIG.4637R}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Molnar et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Molnar et al., 2007)

Mutagen

in vitro construct

(Molnar et al., 2007)

Progenitor genotype

Carried in construct

P{NIG.4637R}

Cytology

Description

UASt regulatory sequences drive expression of a hh RNAi construct.

(Molnar et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-4637R

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size, with Scer\GAL4^MD-638

(Molnar et al., 2011)

visible, with Scer\GAL4^MD-638

(Molnar et al., 2011)

Phenotype Manifest In

anterior crossvein, with Scer\GAL4^MD-638

(Molnar et al., 2007)

first posterior wing cell, with Scer\GAL4^MD-638

(Molnar et al., 2011)

wing blade, with Scer\GAL4^MD-638

(Molnar et al., 2011)

wing vein L3, with Scer\GAL4^MD-638

(Molnar et al., 2007)

wing vein L4, with Scer\GAL4^MD-638

(Molnar et al., 2007)

Detailed Description

Statement

Reference

Expression of hh^NIG.4637R does not significantly affect wing patterning (driven by Scer\GAL4^nub-AC-62 or Scer\GAL4^da.G32) or thermal allodynia (driven by Scer\GAL4^ppk.1.9, even with co-expression of hh^GD193).

(Im et al., 2015)

Expression of hh^NIG.4637R under the control of Scer\GAL4^MD-638 causes a reduction in wing size and in the distance between the veins L3 and L4.

(Molnar et al., 2011)

Expression of hh^NIG.4637R in the wing under the control of Scer\GAL4^MD-638 result in wing size reduction, shortening of the distance between L3 and L4, and loss of the anterior cross vein.

(Molnar et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^MD-638, hh^NIG.4637R has abnormal size phenotype, enhanceable by krz^UAS.cMa/Scer\GAL4^MD-638

(Molnar et al., 2011)

Scer\GAL4^MD-638, hh^NIG.4637R has visible phenotype, enhanceable by krz^UAS.cMa/Scer\GAL4^MD-638

(Molnar et al., 2011)

NOT Enhanced by

Statement

Reference

Scer\GAL4^MD-638, hh^NIG.4637R has visible phenotype, non-enhanceable by Scer\GAL4^MD-638/krz^RNAi.UAS

(Molnar et al., 2011)

Scer\GAL4^MD-638, hh^NIG.4637R has abnormal size phenotype, non-enhanceable by Scer\GAL4^MD-638/krz^RNAi.UAS

(Molnar et al., 2011)

NOT suppressed by

Statement

Reference

Scer\GAL4^MD-638, hh^NIG.4637R has visible phenotype, non-suppressible by Scer\GAL4^MD-638/krz^RNAi.UAS

(Molnar et al., 2011)

Scer\GAL4^MD-638, hh^NIG.4637R has abnormal size phenotype, non-suppressible by Scer\GAL4^MD-638/krz^RNAi.UAS

(Molnar et al., 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^MD-638, hh^NIG.4637R has wing blade phenotype, enhanceable by krz^UAS.cMa/Scer\GAL4^MD-638

(Molnar et al., 2011)

Scer\GAL4^MD-638, hh^NIG.4637R has first posterior wing cell phenotype, enhanceable by krz^UAS.cMa/Scer\GAL4^MD-638

(Molnar et al., 2011)

Scer\GAL4^MD-638, hh^NIG.4637R has wing vein L3 phenotype, enhanceable by Gprk2^RNAi.UAS.cMa, Scer\GAL4^MD-638

(Molnar et al., 2007)

Scer\GAL4^MD-638, hh^NIG.4637R has wing vein L4 phenotype, enhanceable by Gprk2^RNAi.UAS.cMa, Scer\GAL4^MD-638

(Molnar et al., 2007)

Scer\GAL4^MD-638, hh^NIG.4637R has anterior crossvein phenotype, enhanceable by Gprk2^RNAi.UAS.cMa, Scer\GAL4^MD-638

(Molnar et al., 2007)

NOT Enhanced by

Statement

Reference

Scer\GAL4^MD-638, hh^NIG.4637R has wing blade phenotype, non-enhanceable by Scer\GAL4^MD-638/krz^RNAi.UAS

(Molnar et al., 2011)

Scer\GAL4^MD-638, hh^NIG.4637R has first posterior wing cell phenotype, non-enhanceable by Scer\GAL4^MD-638/krz^RNAi.UAS

(Molnar et al., 2011)

NOT suppressed by

Statement

Reference

Scer\GAL4^MD-638, hh^NIG.4637R has wing blade phenotype, non-suppressible by Scer\GAL4^MD-638/krz^RNAi.UAS

(Molnar et al., 2011)

Scer\GAL4^MD-638, hh^NIG.4637R has first posterior wing cell phenotype, non-suppressible by Scer\GAL4^MD-638/krz^RNAi.UAS

(Molnar et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

The wing phenotypes resulting from the expression of hh^NIG.4637R under the control of Scer\GAL4^MD-638 are not modified by the co-expression of krz^{dsRNA.Scer\UAS}.

The wing phenotypes resulting from the expression of hh^NIG.4637R under the control of Scer\GAL4^MD-638 are augmented when krz^Scer\UAS.cMa is co-expressed.

(Molnar et al., 2011)

Expression of Gprk2^{dsRNA.Scer\UAS} in flies expressing hh^NIG.4637R in the wing under the control of Scer\GAL4^MD-638 strongly enhances the wing vein phenotype.

(Molnar et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

NIG-Fly

4637R-1

P{NIG.4637R}1

4637R-2

P{NIG.4637R}2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

hh^NIG.4637R

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

Open Close