FB2026_02 , released June 18, 2026
Allele: Dmel\Sec23CK
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General Information
Symbol
Dmel\Sec23CK
Species
D. melanogaster
Name
FlyBase ID
FBal0244810
Feature type
allele
Associated gene
Dmel\Sec23
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Norum et al., 2010)
Mutagen
P-element activity
(Norum et al., 2010)
Progenitor genotype
Cytology
Description

Has a deletion of G2076 of the coding sequence causing a frame shift that changes the peptide sequence after K692.

(Norum et al., 2010)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:5,651,646..5,651,646 [+]
Comment:

Reported as a deletion of G2076. The deletion causes a frameshift after L692 and the next two new residues are CK.

(Norum et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous, sec239G/sec23CK or sec23CK/Df(3R)ED5187 animals exhibit the same defects. Mutant embryos produce a discontinuous or thin larval cuticle, tracheae do not become air-filled and are barely visible, and the head skeleton is less melanised (though has normal morphology). Ventral denticles and dorsal hairs are missing, though the surface is not smooth but wrinkly. There is reduced chitin in the epidermis and trachea. Animals die at the first instar larval stage within the egg case.

      (Norum et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Sec23CK
      hauCK
      (Norum et al., 2010)
      sec23CK
      Name Synonyms
      Secondary FlyBase IDs
        References (1)