FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\Nrx-1RNAi.UAS
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General Information
Symbol
Dmel\Nrx-1RNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0245100
Feature type
allele
Associated gene
Dmel\Nrx-1
Associated Insertion(s)
Carried in Construct
P{UAS-nrx.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Chen et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Chen et al., 2010)
Mutagen
in vitro construct
(Chen et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-nrx.RNAi}
Cytology
Description

UAS regulatory sequences drive expression of a tail-to-tail inverted repeat of Nrx-1 sequence.

(Chen et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nrx-1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Neuromuscular junction (NMJ) size and the number of active zones/NMJ are significantly reduced compared to wild type in embryos expressing Nrx-1dsRNA.Scer\UAS under the control of Scer\GAL4elav.PLu, while active zone density within the NMJ and active zone size are unaffected.

      The amplitude of the evoked excitatory junction current (EJC) at the NMJ is reduced compared to wild type, in embryos expressing Nrx-1dsRNA.Scer\UAS under the control of Scer\GAL4elav.PLu, while the frequency of spontaneous EJCs is unaffected. There is no change in the amplitude of glutamate-gated currents at the NMJ in embryos expressing Nrx-1dsRNA.Scer\UAS under the control of Scer\GAL4elav.PLu.

      Expression of Nrx-1dsRNA.Scer\UAS under the control of Scer\GAL4how-24B has no effect on NMJ morphology or electrophysiological properties.

      (Chen et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Nrx-1RNAi.UAS
      Nrx-1dsRNA.Scer\UAS
      Nrx-1dsRNA.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)