FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HDAC36C
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General Information
Symbol
Dmel\HDAC36C
Species
D. melanogaster
Name
FlyBase ID
FBal0245123
Feature type
allele
Associated gene
Dmel\HDAC3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Zhu et al., 2008)
Progenitor genotype
Caused by aberration
Df(3R)Hdac36C
Cytology
Description

Imprecise excision of P{PZ}Snr101319 results in an approximate 1.8kb deletion, removing about two-thirds of the Hdac3 coding region (breaking at codon 145 within the HDAC catalytic domain) plus all Snr1 DNA 3' to the original insertion.

(Zhu et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:5,471,952..5,473,759 [-]
Comment:

~1.8kb deletion resulting from the imprecise excision of P{PZ}Snr101319. One boundary is in Snr1 and one is in HDAC3. The boundary within HDAC3 was reported as breaking at codon 145 and is approximate.

(Zhu et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hdac36C homozygous third instar wandering larvae display a small disc phenotype.

      (Zhu et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      HDAC36C has imaginal disc | third instar larval stage phenotype, non-suppressible by Snr1+t8.9

      (Zhu et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for Hdac36C leads to strong suppression of the eye colour variegation found in In(1)wm4 mutants.

      Hdac36C/Rpd33-10 double mutants show complete suppression of In(1)wm4 eye colour variegation.

      The presence of Snr1+t8.9 does not suppress the small disc phenotype found in Hdac36C homozygous third instar wandering larvae.

      (Zhu et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      HDAC36C
      Hdac36C
      (Zhu et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)